{
  "name": "Addison's Disease",
  "slug": "addisons-disease",
  "url": "https://nursingplex.com/care-plans/addisons-disease",
  "category": "Endocrine & Metabolic",
  "summary": "Adrenal insufficiency causing hypotension, hyponatremia and fatigue; steroid replacement and crisis prevention.",
  "nursing_diagnoses": [
    "Deficient fluid volume",
    "Activity intolerance",
    "Risk for injury"
  ],
  "overview": [
    "Addison's disease, or primary adrenal insufficiency, occurs when the adrenal cortex is progressively destroyed — most often by autoimmune attack, but also by infection, hemorrhage or metastatic disease — and can no longer produce adequate cortisol and aldosterone. Because both major corticosteroid hormones are lost, the disease affects glucose regulation, stress response, blood pressure, and sodium and potassium balance simultaneously.",
    "Symptoms develop insidiously: fatigue, weight loss, low blood pressure, salt craving and a characteristic bronze hyperpigmentation caused by excess ACTH stimulating melanocytes. The danger is the addisonian crisis — a sudden, life-threatening drop in cortisol precipitated by infection, trauma, surgery or abrupt steroid withdrawal, presenting with severe hypotension, vomiting, profound weakness and vascular collapse.",
    "Nursing care requires vigilance for the subtle chronic presentation as well as rapid recognition and treatment of crisis. Lifelong hormone replacement is the cornerstone of management, and patient education about stress dosing and never abruptly stopping steroids is what prevents most crises from occurring in the first place."
  ],
  "key_facts": [
    {
      "label": "Cause",
      "text": "Autoimmune destruction of the adrenal cortex is the most common cause in developed countries; also infection (TB), hemorrhage or metastasis."
    },
    {
      "label": "Hallmark sign",
      "text": "Hyperpigmentation of skin, especially in creases, scars and pressure points, from excess ACTH."
    },
    {
      "label": "Electrolytes",
      "text": "Hyponatremia, hyperkalemia and hypoglycemia are classic, reflecting aldosterone and cortisol deficiency."
    },
    {
      "label": "Addisonian crisis",
      "text": "Severe hypotension, shock, abdominal pain, vomiting and altered mental status; a true endocrine emergency requiring immediate IV hydrocortisone and fluids."
    },
    {
      "label": "Stress dosing",
      "text": "Cortisol replacement must be increased during illness, surgery or major stress; failure to do so is a leading cause of crisis."
    }
  ],
  "nursing_priorities": [
    "Recognize and treat addisonian crisis immediately if it occurs.",
    "Administer corticosteroid and mineralocorticoid replacement as prescribed and never abruptly discontinue them.",
    "Monitor fluid, electrolyte and glucose status closely.",
    "Protect from infection and stress that could precipitate crisis.",
    "Educate the patient about stress dosing and lifelong hormone therapy.",
    "Monitor blood pressure for orthostatic changes and prevent falls.",
    "Support nutrition and manage gastrointestinal symptoms."
  ],
  "assessment": {
    "subjective": [
      "Chronic fatigue and progressive weakness not relieved by rest",
      "Unintentional weight loss and loss of appetite",
      "Nausea, vomiting, abdominal pain or diarrhea",
      "Salt craving",
      "Dizziness or lightheadedness on standing",
      "Depression, irritability or difficulty concentrating"
    ],
    "objective": [
      "Hyperpigmentation of skin, gums, scars and pressure areas",
      "Hypotension, especially orthostatic drop in blood pressure",
      "Hyponatremia and hyperkalemia on laboratory studies",
      "Hypoglycemia",
      "Weight loss and evidence of dehydration",
      "Tachycardia progressing to signs of shock during crisis",
      "Fever, confusion or coma during addisonian crisis"
    ],
    "related_factors": [
      "Autoimmune destruction of the adrenal cortex",
      "Infectious destruction of adrenal tissue, such as tuberculosis",
      "Adrenal hemorrhage, surgical removal, or metastatic infiltration",
      "Abrupt discontinuation of long-term exogenous corticosteroid therapy",
      "Physiologic stress from infection, trauma or surgery unmatched by adequate steroid replacement"
    ]
  },
  "goals": [
    "The client will maintain stable blood pressure without orthostatic symptoms.",
    "The client will maintain electrolyte and glucose levels within normal limits.",
    "The client will remain free of addisonian crisis or will be promptly recognized and treated if it occurs.",
    "The client will verbalize understanding of lifelong hormone replacement and stress dosing.",
    "The client will identify signs and symptoms requiring immediate medical attention.",
    "The client will maintain adequate nutrition and stable weight."
  ],
  "interventions": [
    {
      "title": "1. Recognizing and managing addisonian crisis",
      "points": [
        "Monitor for sudden severe hypotension, shock, abdominal pain, vomiting and altered mental status, which signal an evolving crisis requiring emergency treatment.",
        "Administer IV hydrocortisone and aggressive isotonic fluid resuscitation immediately as ordered; delay increases mortality risk.",
        "Correct hypoglycemia and hyperkalemia as directed while monitoring cardiac rhythm for potassium-related changes.",
        "Identify and treat the precipitating stressor, such as infection, that triggered the crisis.",
        "Continue close hemodynamic monitoring until the patient is stabilized on maintenance therapy."
      ]
    },
    {
      "title": "2. Hormone replacement management",
      "points": [
        "Administer glucocorticoid and mineralocorticoid replacement on schedule; missed doses can precipitate deterioration.",
        "Teach that doses must never be stopped abruptly, even when the patient feels well, because the adrenal glands cannot compensate.",
        "Educate on stress dosing — increasing the glucocorticoid dose during illness, injury, surgery or significant emotional stress — and provide clear written instructions for how much to increase and when to seek help.",
        "Ensure the patient has access to an injectable emergency hydrocortisone kit and knows how and when to use it.",
        "Coordinate with the prescriber before any planned surgery or procedure to arrange perioperative stress-dose coverage."
      ]
    },
    {
      "title": "3. Fluid, electrolyte and glucose monitoring",
      "points": [
        "Monitor daily weights, intake and output, and orthostatic vital signs to detect volume depletion early.",
        "Trend serum sodium, potassium and glucose, reporting significant abnormalities promptly.",
        "Encourage adequate sodium intake as directed, particularly during hot weather or vigorous activity when sodium losses increase.",
        "Watch for hypoglycemia symptoms such as shakiness, diaphoresis and confusion, and provide readily available carbohydrate sources."
      ]
    },
    {
      "title": "4. Preventing precipitating stressors",
      "points": [
        "Protect from infection through hand hygiene, minimizing exposure to ill contacts, and prompt treatment of any infection that develops.",
        "Assess for and manage sources of physical or emotional stress that could increase cortisol demand.",
        "Rise slowly from lying or sitting to standing to reduce orthostatic symptoms and fall risk.",
        "Space activities with rest periods to conserve energy during the chronic fatigue phase."
      ]
    },
    {
      "title": "5. Nutrition and psychosocial support",
      "points": [
        "Offer small, frequent, nutrient-dense meals to address appetite loss and support weight stabilization.",
        "Encourage foods naturally higher in sodium as directed by the provider, particularly during illness.",
        "Address mood changes and provide reassurance that irritability and depression can improve with proper hormone replacement.",
        "Involve family in recognizing early crisis symptoms so they can seek help quickly."
      ]
    }
  ],
  "patient_teaching": [
    "Take replacement hormones exactly as prescribed, at the same times each day, and never stop them abruptly.",
    "Learn stress-dosing rules: increase your glucocorticoid dose during illness, fever, injury or major stress, and know when to give yourself the emergency injection.",
    "Wear a medical alert bracelet or necklace identifying adrenal insufficiency at all times.",
    "Carry an emergency hydrocortisone injection kit and ensure family members know how to administer it if you cannot.",
    "Recognize early crisis warning signs — severe weakness, vomiting, abdominal pain, dizziness — and seek emergency care immediately if they occur.",
    "Maintain adequate salt and fluid intake, especially during hot weather, illness or vigorous exercise.",
    "Inform every healthcare provider, including dentists, about your diagnosis before any procedure or surgery.",
    "Keep regular follow-up appointments for hormone level monitoring and dose adjustment."
  ]
}