A 16-year-old girl presents to the psychiatric-mental health nurse practitioner with a chief complaint of depression. During the psychiatric evaluation, the client states that she is taking a medication the PMHNP recognizes as a depression-inducer. Which of the following medications possibly induced depression in this client?

Choice A reason: Dextromethorphan is a cough suppressant with NMDA antagonist properties. While it can cause dissociation or mood changes at high doses, it is not commonly associated with inducing depression. Choice B reason: Diphenhydramine is an antihistamine that may cause sedation or cognitive dulling but is not typically linked to depressive symptoms. Choice C reason: Isotretinoin, used for severe acne, has been associated with psychiatric side effects including depression and suicidal ideation, particularly in adolescents. Its neuropsychiatric risk profile is well-documented and warrants close monitoring. Choice D reason: Pseudoephedrine is a decongestant that may cause agitation or insomnia but is not known to induce depression.