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    Ati pharmacology proctored exam

    A 2 month old patient with current active infection. Being treated with Neomycin. The nurse understands that neomycin may cause serious adverse effects such as ___ and ___.

    Explanation & Rationale

    i) Neurotoxicity: Neomycin, an aminoglycoside antibiotic, can lead to neurotoxicity, manifesting as muscle weakness or respiratory paralysis due to its effects on neuromuscular transmission. This risk is especially significant in vulnerable populations like infants or clients with impaired renal function. ii) Nephrotoxicity: Neomycin is known for its potential to cause kidney damage due to its accumulation in renal tubular cells, leading to acute tubular necrosis. Monitoring renal function is critical when administering this medication, particularly in young children who are more susceptible to such effects. Incorrect: Hepatotoxicity: Neomycin is not associated with liver toxicity, as it primarily affects the kidneys and nervous system. Cardiotoxicity: This is not a recognized adverse effect of neomycin. Dermatotoxicity: While aminoglycosides may cause mild skin irritation, serious dermatotoxicity is not typical for neomycin. Ototoxicity: Though highly relevant to other aminoglycosides, ototoxicity is less pronounced with neomycin because it is minimally absorbed systemically when used topically or orally. Hemotoxicity: Neomycin is not known to directly affect blood components.

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