A 21-year-old patient with a history of asthma presents with sudden onset shortness of breath and difficulty breathing. Which characteristics would help the nurse practitioner make a differential diagnosis of an anaphylactic reaction?

Choice A reason: Crackles are indicative of pulmonary edema or infection, not typically anaphylaxis. Choice B reason: Diffuse bilateral opacities suggest pneumonia or acute respiratory distress syndrome, not anaphylaxis. Choice C reason: Low-grade fever and facial pain are more consistent with sinus infection or upper respiratory illness. Choice D reason: This is correct. Anaphylaxis presents with sudden onset of symptoms including orofacial swelling, urticaria or rash, and pruritus, often accompanied by respiratory compromise and hypotension.