A 22 kg patient has an order for cefazolin 500 mg IV every 6 hours. The safe dose is 50 mg/kg/day. Is the ordered dose safe for the patient?

Calculate the Maximum Safe Daily Dose (mg/day) Patient weight: 22 kg Maximum safe dose: 50 mg/kg/day Maximum Safe Daily Dose = 22 kg x 50 mg/kg/day = 1,100 mg/day Calculate the Total Ordered Daily Dose (mg/day) Ordered dose per administration: 500 mg Frequency: Every 6 hours (4 doses per day) Total Ordered Daily Dose = 500 mg/dose x 4 doses/day = 2,000 mg/day The Total Ordered Daily Dose (2,000 mg/day) is greater than the Maximum Safe Daily Dose (1,100 mg/day). The ordered dose is unsafe.