A 24-year-old woman is admitted to the hospital for a complete medical examination. Her current complaints are indicative of SLE. Which symptom would indicate this diagnosis?

A. Musculoskeletal pain in the hands: Polyarthralgia (joint pain), particularly in the small joints of the hands, is one of the most common early clinical manifestations of SLE. B. Recent weight gain of 10 lb: SLE patients more commonly experience weight loss due to systemic inflammation and illness. C. Frequent episodes of diarrhea: Gastrointestinal symptoms are less specific to SLE than joint and skin manifestations. D. Difficulty breathing in the morning: While SLE can cause pleurisy, "morning breathing difficulty" is more indicative of COPD or asthma; lupus joint stiffness is what is typically worse in the morning.