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    Pharmacology proctored examQuestion 18
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    Pharmacology proctored exam
    Select All That Apply

    A 26-year-old female patient noted restless, marching in place while standing, and foot tapping. The PMHNP collectively recognizes these are symptoms of akathisia. Which of the following would be most appropriate for treatment of akathisia? (Select all that applies)

    Explanation & Rationale

    A. B-adrenergic blockers: Beta-blockers, particularly propranolol, are effective in reducing the motor restlessness and inner tension associated with akathisia. They work by modulating central adrenergic activity and are often considered first-line treatment for this side effect. B. Diphenhydramine: Diphenhydramine is primarily effective for dystonia and Parkinsonism caused by antipsychotics due to its anticholinergic properties. It is generally less effective for akathisia, which is thought to be mediated more by dopaminergic and adrenergic pathways. C. Benztropine: Benztropine is an anticholinergic used to manage extrapyramidal symptoms such as dystonia and Parkinsonism. It has limited efficacy in akathisia, which is largely non-cholinergic in origin. D. Benzodiazepines: Benzodiazepines, such as lorazepam or clonazepam, help alleviate akathisia by reducing anxiety and promoting muscle relaxation. They are particularly useful when beta-blockers are contraindicated or insufficient.

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