A 41-year-old man presents to the PMHNP with new-onset depression and motor abnormalities. These symptoms are indicative of which disorder?

Choice A reason: Neurosyphilis can cause neuropsychiatric symptoms but typically presents with a broader spectrum including sensory deficits and gait disturbances. Choice B reason: Kuru is a prion disease historically seen in Papua New Guinea with tremors and ataxia, not a common diagnosis elsewhere. Choice C reason: Huntington’s disease presents with movement disorders (chorea), cognitive decline, and psychiatric symptoms such as depression, often in midlife. Choice D reason: HIV-associated neurocognitive disorder may cause cognitive deficits but motor abnormalities are less specific and occur later in disease progression.