A 53-year-old woman of Asian descent was recently diagnosed with osteoporosis. When should treatment for this disease begin?

Choice A reason: Osteoporosis treatment is recommended for patients with a t-score of -2.5 or below, which indicates significant bone density loss and a high risk of fractures. Choice B reason: While a history of fragility fracture indicates high risk, treatment is often initiated based on bone density criteria even in the absence of fracture. Choice C reason: Patients with osteopenia may receive treatment based on fracture risk, but the threshold is typically higher than 1%, and clinical guidelines focus on t-score criteria or significant risk factors. Choice D reason: Age alone, even if older than 65, is not sufficient for treatment unless accompanied by diagnostic criteria or fractures. Symptomatic presentation is not the primary trigger for therapy.