A 6-month-old child has developed skin irritation due to an allergic reaction. He has been prescribed a topical skin ointment. The nurse will consider which of the following before administering the drug?

A. Infants actually have a larger body surface area relative to their weight compared with adults, which increases the potential for systemic absorption of topical medications, not less. B. Infants have increased absorption rates of topical drugs due to their thin, more permeable skin, so decreased absorption is incorrect. C. Infant skin is thinner, more hydrated, and has a greater permeability, making them more susceptible to systemic effects of topical medications; the nurse must carefully calculate dosage and avoid prolonged or extensive application. D. Infants have a higher proportion of total body water compared with adults, not lower; this influences distribution of water-soluble drugs, but it is less relevant for topical absorption.