A cancer patient asks the nurse what can be given to alleviate severe, chronic pain of several months’ duration. The patient has been taking oxycodone (OxyContin) and states it is no longer effective. The nurse will suggest discussing which medication with the provider?

Choice A reason: Pentazocine is less effective for severe, chronic pain and has mixed agonist-antagonist effects. Fentanyl is stronger for opioid-tolerant patients, so this is incorrect. Choice B reason: Hydrocodone is weaker than oxycodone and inadequate for severe, resistant pain. Fentanyl’s potency suits chronic cancer pain, so this is incorrect. Choice C reason: Fentanyl transdermal is potent, long-acting, and ideal for severe, chronic cancer pain in opioid-tolerant patients. It’s appropriate here, making it the correct choice. Choice D reason: Meperidine is not recommended for chronic pain due to neurotoxic metabolites. Fentanyl is safer and more effective, so this is incorrect.