A child weighing 52.5 pounds receives a prescription for asparaginase 4,780 IU IV. The vial is labeled, "Asparaginase 10,000 IU single use vial. For IM use, reconstitute in 2 mL sterile sodium chloride, and for IV use, reconstitute in 5 mL." How many mL should the nurse administer? (Enter the numeric value only. If rounding is required, round to the nearest tenth.)

Calculation: Identify the prescribed dose and reconstitution instructions Prescribed Dose: 4,780 IU Vial: 10,000 IU reconstituted in 5 mL for IV Concentration = 10,000 ÷ 5 = 2,000 IU/mL Calculate the volume to administer Volume to administer = Ordered Dose ÷ Concentration Volume to administer = 4,780 ÷ 2,000 = 2.39 mL Round to the nearest tenth = 2.4 mL