A client diagnosed with Parkinson's disease receives a prescription for carbidopa-levodopa, controlled release (CR) 25/100 mg PO daily each morning. Which information should the nurse include in the client's teaching plan? Select all that apply.

Rationale: A. An upset stomach may occur as a side effect of this medication: Levodopa commonly causes gastrointestinal upset, especially when first starting treatment. Taking it with a small snack (not high-protein) may reduce nausea, though the CR formulation tends to be gentler on the stomach. B. A change in urine color to dark red often occurs while taking this drug: Carbidopa-levodopa can cause harmless discoloration of urine, sweat, or saliva to a red, brown, or black color. Clients should be reassured that this is expected and not harmful. C. The medication should only be taken during a meal: Carbidopa-levodopa is best absorbed on an empty stomach. Taking it with food may help with nausea, but high-protein meals interfere with absorption and should be avoided around dosing. D. Avoid sunlight and wear sunglasses while outdoors: This is not a common or significant teaching point specifically for carbidopa-levodopa. While some medications can cause photosensitivity, carbidopa-levodopa is not prominently known for this side effect. E. Parkinson symptoms should diminish within one week: The therapeutic effect of carbidopa-levodopa, especially in CR form, often takes several weeks to reach optimal levels. Symptom improvement within one week is unlikely.