A client diagnosed with strep throat requires antibiotics for treatment. With an allergy to penicillin, the nurse understands which medication should be avoided due to cross-sensitivity with penicillin medications?

A. Macrolides, such as azithromycin and erythromycin, have a low cross-reactivity with penicillin and are typically safe alternatives for those with penicillin allergies. B. Sulfonamides are not structurally similar to penicillins and generally do not have cross-sensitivity issues with penicillin allergies. C. Cephalosporins share a similar beta-lactam structure to penicillins, which can result in cross-sensitivity in some individuals with a penicillin allergy. For this reason, they should be avoided or used with caution in these clients. D. Tetracyclines have a different structure from penicillins and are usually safe for clients with penicillin allergies.