A client has been taking isoniazid (INH) for TB for 3 weeks. What laboratory result needs to be reported to the HCP immediately?
Explanation & Rationale
A. Elevated WBC: An elevated white blood cell count may indicate infection or inflammation but is not a common adverse effect directly linked to isoniazid. It should be evaluated, but it does not require the same urgent response as signs of hepatotoxicity. B. Elevated RBC: An increase in red blood cell count is uncommon and not associated with isoniazid toxicity. It may reflect other physiological processes but is not a priority concern in the context of TB treatment with INH. C. Elevated liver function tests: Isoniazid can cause hepatotoxicity, especially in older adults or when combined with other hepatotoxic drugs. Elevated liver enzymes (e.g., ALT, AST) indicate liver stress or injury and must be reported immediately to prevent progression to severe liver damage. D. Elevated albumin: Elevated albumin levels are generally not clinically significant and rarely occur in acute illness. They do not indicate liver dysfunction and are not relevant to monitoring for isoniazid-related toxicity.