A client has poor blood circulation. The nurse is concerned about which process of pharmacokinetics?

A. Distribution: Distribution refers to the movement of the drug from the bloodstream to tissues and organs. Poor circulation can impair drug distribution, leading to reduced effectiveness or toxic accumulation. B. Excretion: Excretion is the elimination of drugs, primarily through the kidneys. While circulation plays a role, excretion is more directly affected by renal function. C. Metabolism: Metabolism occurs primarily in the liver and is not the primary concern in a client with poor circulation. D. Absorption: Absorption refers to how the drug enters the bloodstream, which is more dependent on the GI tract (oral meds) or injection site (IV, IM meds) rather than circulation.