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    Pharmacology proctored examexamplify (MCPHS university)

    A client is admitted to the hospital with a deep vein thrombosis (DVT) and an intravenous heparin drip is prescribed. Which of the following drugs should be available in the pharmacy if the client begins to bleed?

    Explanation & Rationale

    A. Antithrombin: Antithrombin is a naturally occurring anticoagulant that inactivates thrombin and factor Xa. It is sometimes given to patients with antithrombin deficiency but is not used as an antidote for heparin-induced bleeding. B. Fresh frozen plasma: Fresh frozen plasma contains clotting factors and may be used to manage coagulopathies, but it is not specific to reversing heparin. It might be considered in massive bleeding, but protamine sulfate is the preferred direct antidote. C. Protamine sulfate: Protamine sulfate binds to heparin and neutralizes its anticoagulant effect, making it the drug of choice for reversing heparin-induced bleeding. It is fast-acting and effective in emergencies involving heparin overdose. D. Vitamin K: Vitamin K reverses the effects of warfarin by promoting synthesis of clotting factors. It has no effect on heparin activity and is not useful for treating bleeding caused by heparin administration.

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