A client is prescribed Acyclovir 350 mg IV. The medication available is a 500 mg vial. Package directions states to reconstitute the powder with 20 mL of sterile water and withdraw the desired amount. PART 2: After withdrawing the required dose, add the medication in 100 mL of IV fluid to run over 1 hour. Calculate the rate to set the IV pump.

Calculate the concentration of the reconstituted Acyclovir: You have 500 mg of Acyclovir in 20 mL of sterile water. Concentration = 500 mg / 20 mL = 25 mg/mL Calculate the volume needed for the prescribed dose: Desired dose: 350 mg Volume (mL) = Desired dose / Concentration Volume (mL) = 350 mg / 25 mg/mL = 14 mL Calculate the total volume for infusion: The 14 mL of Acyclovir is added to 100 mL of IV fluid. Total volume = 14 mL + 100 mL = 114 mL Determine the infusion time in hours: The infusion is to run over 1 hour. Calculate the IV pump rate in mL/hr: IV pump rate (mL/hr) = Total volume (mL) / Infusion time (hr) IV pump rate = 114 mL / 1 hr = 114 mL/hr