A client is prescribed lansoprazole 15 mg PO once a day. At which of the following times should the nurse administer the medication?

Rationale: A. Lansoprazole is a proton pump inhibitor (PPI) that works best when given before meals, ideally 30–60 minutes prior to the first meal of the day, to maximize inhibition of gastric acid secretion. B. Taking lansoprazole at night does not optimize its effect because acid production is highest in the morning. C. Administering with food reduces absorption and efficacy of the medication. D. PPIs should be taken before the meal, not after, to ensure maximum acid suppression.