A client is receiving chemotherapy through a peripheral IV line. What action by the nurse is most important?

Rationale: A. Teaching about chemotherapy side effects is an essential nursing role but not the most immediate priority when the drug is being administered. Client safety during infusion takes precedence over education. B. Nausea and vomiting are common chemotherapy side effects, but these symptoms do not pose an immediate risk for tissue injury or necrosis. They can be managed after ensuring safe drug delivery. C. The most important action is to frequently assess the IV site and verify blood return during chemotherapy administration, especially when using a peripheral IV. Many chemotherapeutic agents are vesicants, meaning they can cause severe tissue necrosis if extravasation occurs. Hourly assessment for redness, swelling, or pain helps detect infiltration early and prevent serious complications. Ensuring blood return confirms proper catheter placement within the vein. D. Comfort measures are beneficial but not the priority. Applying warmth could worsen extravasation if infiltration has already occurred, leading to more tissue damage.