A client is receiving metronidazole for Clostridium difficile pseudomembranous colitis. Which information should the nurse include in this client's medication teaching plan?

A. Take one hour after eating: Metronidazole can be taken with or without food, although taking it with meals may reduce gastrointestinal upset. There is no specific requirement to take it one hour after eating, so this is not a key teaching point. B. Keep medication refrigerated: Metronidazole tablets and capsules do not require refrigeration and should be stored at room temperature away from moisture and heat. This instruction would not be applicable for typical outpatient oral formulations. C. Avoid the use of alcohol: Combining metronidazole with alcohol can cause a disulfiram-like reaction, resulting in severe nausea, vomiting, flushing, tachycardia, and hypotension. Clients should avoid alcohol during treatment and for at least 48 hours after the last dose. D. Drink a liter of water daily: Adequate hydration is beneficial for overall health but is not a specific or critical teaching point for metronidazole use. The priority instruction is related to avoiding alcohol due to the risk of a serious adverse reaction.