A client is receiving metronidazole for Clostridium difficile pseudomembranous colitis. Which information should the nurse include in this client's medication teaching plan?

A. Drink a liter of water daily: While maintaining hydration is generally important, there is no specific requirement to drink exactly one liter of water daily related to metronidazole therapy. Encouraging adequate fluid intake is good, but it is not unique to this medication. B. Keep medication refrigerated: Metronidazole tablets do not require refrigeration and should be stored at room temperature, away from moisture and heat. Advising refrigeration could lead to improper storage and potential medication degradation. C. Avoid the use of alcohol: Metronidazole can cause a severe disulfiram-like reaction when combined with alcohol, leading to symptoms such as nausea, vomiting, flushing, and headache. Clients must avoid alcohol during treatment and for at least 48 hours afterward. D. Take one hour after eating: Metronidazole absorption is not significantly affected by food, and it can be taken with or without meals. This instruction is unnecessary and could complicate adherence.