A client is receiving tPA for a embolic stroke. Which adverse effect of tPA should the nurse assess the client for?

A. Skin rash with urticaria: While allergic reactions like rash or urticaria can occur, they are relatively rare with tPA. This is not the most common or most serious adverse effect associated with thrombolytic therapy. B. Wheezing and labored respirations: These symptoms may suggest anaphylaxis, which is a rare but severe reaction to any IV medication. However, tPA is far more commonly associated with bleeding complications than respiratory distress. C. Bruising and epistaxis: tPA (tissue plasminogen activator) promotes fibrinolysis and significantly increases the risk of bleeding. Bruising and nosebleeds are common signs of excessive anticoagulation or bleeding and are key adverse effects to monitor closely during tPA administration. D. Temperature elevation of 100.8°F: A mild fever may occur after a stroke, but it is not directly related to tPA administration. While fever should be addressed, it is not a primary concern associated with the medication’s adverse effects.