A client ordered grapefruit juice for breakfast. The nurse should review the client's medication record for medications metabolized by the:

B. Liver: Grapefruit juice inhibits CYP3A4 enzymes in the liver, which metabolize many drugs (e.g., statins, calcium channel blockers). This inhibition can lead to increased drug levels and toxicity. A. Gall bladder – The gall bladder stores bile but does not metabolize drugs. C. Kidney – The kidneys excrete drugs, but grapefruit juice does not significantly impact renal metabolism. D. Small bowel – Some drug metabolism occurs in the intestines, but grapefruit juice primarily affects liver enzymes.