A client presents to the clinic with fatigue, poor appetite, general malaise, and vague joint pain that improves mid-morning. The client has been taking over-the-counter ibuprofen for several months. The healthcare provider makes an initial diagnosis of rheumatoid arthritis (RA). Which laboratory test(s) should the nurse report to the healthcare provider? Select all that apply.

A. C-reactive protein: CRP is a marker of systemic inflammation and is often elevated in autoimmune conditions like RA, helping to assess disease activity and guide treatment decisions. B. D-Dimer: D-Dimer is used primarily to assess for clotting disorders such as deep vein thrombosis or pulmonary embolism and is not relevant to the diagnosis or monitoring of RA. C. White blood cell count: An elevated or suppressed WBC count may indicate systemic inflammation or immunosuppression, both of which can occur in RA and affect treatment planning. D. Anti-cyclic citrullinated peptide (anti-CCP) antibodies: Anti-CCP antibodies are highly specific for RA and can often be detected early in the disease, making them a valuable diagnostic marker. E. Sedimentation rate: An elevated erythrocyte sedimentation rate (ESR) is a nonspecific but useful indicator of ongoing inflammation in RA and is commonly used to monitor disease activity.