A client presents to the clinic with fatigue, poor appetite, general malaise, and vague joint pain that improves mid-morning. The client has been taking over-the-counter Ibuprofen for several months. The healthcare provider makes an initial diagnosis of rheumatoid arthritis (RA). Which laboratory test(s) should the nurse report to the healthcare provider? Select all that apply.

A. Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific for rheumatoid arthritis (RA). A positive result supports the diagnosis of RA. B. C-reactive protein is an inflammatory marker that is elevated in active RA, reflecting inflammation in the body. C. Sedimentation rate (ESR) is also an inflammatory marker and is often elevated in RA, indicating active inflammation. D. D-Dimer is a test that assesses for the presence of clot formation and breakdown. It is not used for diagnosing RA. E. White blood cell count may be slightly elevated in RA due to inflammation, but it is not specific for RA and is less helpful in the diagnosis compared to the other tests.