A client presents to the emergency department in sickle cell crisis. Which of the following interventions should the nurse implement? (Select all that apply.)

Choice A reason: Starting IV saline is essential to maintain hydration, which helps reduce blood viscosity and prevent further sickling of red blood cells. Adequate fluid resuscitation is a cornerstone of sickle cell crisis management. Choice B reason: Administering oxygen helps prevent hypoxia, which can exacerbate sickling and worsen the crisis. Oxygen therapy supports tissue perfusion and reduces complications. Choice C reason: Pain management is critical in sickle cell crisis due to the intense pain caused by vaso-occlusion. Opioids are often required to control pain and improve patient comfort. Choice D reason: Removing constrictive clothing promotes circulation and reduces external pressure that could worsen ischemia. It is a simple but effective supportive measure. Choice E reason: Cooling the patient is contraindicated. Cold temperatures can trigger or worsen sickling by causing vasoconstriction. Patients should be kept warm to promote vasodilation and circulation.