A client presents to the healthcare setting with a diagnosis of chronic liver failure. The nurse understands this will affect which step of pharmacokinetics?

A. While liver failure may affect excretion indirectly, it primarily impacts metabolism more significantly. B. Absorption is typically not directly affected by liver function, though it can be influenced by other factors. C. The liver is crucial for drug metabolism; chronic liver failure impairs the liver's ability to metabolize medications effectively, leading to potential toxicity. D. Distribution may be altered due to changes in plasma proteins or blood flow, but the most significant impact occurs in metabolism.