A client receives a prescription for methotrexate. Which information provided by the client requires additional instruction by the nurse?

A. Store the medication at room temperature: Methotrexate tablets are stable at room temperature when stored in a dry place, making this instruction appropriate. There is no need for refrigeration unless otherwise specified for certain formulations. B. Use folic acid to protect the liver: Folic acid is recommended with methotrexate to reduce the risk of adverse effects such as mouth sores, gastrointestinal upset, and hepatic toxicity. This practice is evidence-based and supports long-term medication tolerance. C. Obtain a platelet count weekly: Methotrexate can cause bone marrow suppression, so frequent monitoring of platelets is important early in therapy to detect hematologic toxicity. This instruction aligns with safe medication management. D. Take the medication during pregnancy: Methotrexate is highly teratogenic and can cause severe fetal malformations or pregnancy loss. It is strictly contraindicated in pregnancy, and clients must use effective contraception and avoid conception during and for a period after therapy.