A client receiving a norepinephrine infusion through a peripheral IV reports burning pain and swelling at the IV site. The nurse suspects medication extravasation. Which medication should the nurse anticipate being administered to prevent tissue necrosis?

Rationale: A. Phentolamine: Phentolamine is an alpha-adrenergic antagonist that works by blocking the vasoconstrictive effects of norepinephrine at the extravasation site. Administering phentolamine subcutaneously around the affected area helps restore local blood flow, prevent ischemia, and reduce the risk of tissue necrosis caused by prolonged vasoconstriction. B. Prazosin: Prazosin is an oral alpha-1 adrenergic blocker used primarily for hypertension and benign prostatic hyperplasia. It is not indicated for acute treatment of norepinephrine extravasation and would not provide immediate local vasodilation to prevent tissue damage. C. Protamine sulfate: Protamine sulfate is a reversal agent for heparin and other anticoagulants. It has no effect on alpha-adrenergic receptor-mediated vasoconstriction and cannot prevent tissue necrosis caused by norepinephrine extravasation. D. Epinephrine: Epinephrine is a potent alpha- and beta-adrenergic agonist that causes vasoconstriction. Administering epinephrine at the extravasation site would worsen ischemia and increase the risk of tissue necrosis rather than prevent it.