A client reports taking 400 mg of ibuprofen four times a day at home. Which question helps the nurse determine whether the client is experiencing an adverse effect of the medication?

A. "Have you had any ringing in your ears?": Tinnitus is more commonly associated with salicylate (aspirin) toxicity rather than ibuprofen. While high doses of NSAIDs can rarely affect hearing, this is not a primary or common adverse effect to monitor for ibuprofen use. B. "Have you noticed hand tremors?": Tremors are not a known adverse effect of ibuprofen. Asking this question would not provide relevant information regarding the safety or complications of NSAID therapy. C. "What color are your stools?": Dark, tarry stools (melena) can indicate gastrointestinal bleeding, which is a serious and well-documented adverse effect of NSAIDs like ibuprofen. Assessing stool color helps identify potential GI mucosal damage or ulceration early, allowing for timely intervention. D. "Are you urinating more frequently?": Polyuria is not a typical adverse effect of ibuprofen. While NSAIDs can affect renal function, the more relevant assessment would focus on urine output, edema, or signs of kidney injury rather than increased frequency.