A client was admitted to the inpatient unit for depression and is prescribed a selective serotonin reuptake inhibitor (SSRI). Which sign or symptom would the nurse include in the teaching session about serotonin syndrome?

Choice A reason: Impotence is a potential side effect of SSRIs due to serotonin’s effect on sexual function but is not a symptom of serotonin syndrome, a life-threatening condition involving excessive serotonin causing hyperthermia, agitation, and muscle rigidity, making this incorrect. Choice B reason: Hypotension is not a primary symptom of serotonin syndrome, which involves serotonin excess leading to hyperthermia, tremors, and autonomic instability. Hypotension may occur secondary to severe cases but is not a hallmark symptom included in teaching. Choice C reason: Fever is a key symptom of serotonin syndrome, caused by excessive serotonin stimulation leading to hyperthermia, muscle rigidity, and autonomic dysfunction. It’s a critical teaching point, as it signals a medical emergency requiring immediate intervention to prevent organ damage. Choice D reason: Constipation is a side effect of some SSRIs due to serotonin’s effect on gastrointestinal motility but is not associated with serotonin syndrome. This condition involves acute neurological and autonomic symptoms, not chronic gastrointestinal issues, making this incorrect.