A client who is newly diagnosed with type 2 diabetes mellitus (DM) receives a prescription for metformin 500 mg PO to Which on should the nurse include in this client's teaching plan? (Select all that apply)

A. Metformin should be taken with meals to reduce gastrointestinal side effects and to improve absorption. B. Sliding scale insulin is not typically initiated at the start of metformin therapy; it is used when blood glucose levels are not controlled by oral medications alone. C. Patients should be aware of the signs and symptoms of hypoglycemia, as it can occur with metformin, especially when combined with other antidiabetic medications or significant lifestyle changes. D. Persistent polyuria can be a sign of uncontrolled diabetes, and patients should report this to their healthcare provider for further assessment. E. Taking an additional dose of metformin for signs of hyperglycemia is not recommended; instead, patients should follow their healthcare provider's instructions for managing high blood sugar levels.