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    Pharmacology proctored exam (examplify)

    A client with a documented anaphylactic reaction to penicillin is prescribed cefazolin for surgical prophylaxis. Which nursing action is most appropriate?

    Explanation & Rationale

    A. Administer cefazolin as ordered, as cross-reactivity is negligible.: Cefazolin is a first-generation cephalosporin with a higher potential for cross-allergy. Administering it without clarification places the client at significant risk for another anaphylactic reaction. B. Hold cefazolin and notify the provider immediately.: The nurse should withhold cefazolin and promptly inform the healthcare provider. Cefazolin shares a similar beta-lactam structure with penicillin, and using it could trigger a severe hypersensitivity response requiring emergency treatment. C. Administer cefazolin with premedication of antihistamines and corticosteroids.: Premedicating does not eliminate the risk of a true IgE-mediated anaphylactic reaction. Such an approach is unsafe as the reaction could still be life-threatening. D. Administer cefazolin slowly with close monitoring for allergic reactions.: Giving the drug slowly does not prevent an anaphylactic response and may delay recognition of symptoms. The safest nursing action is to hold the medication entirely until an alternative antibiotic is prescribed by the healthcare provider.

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