A client with chemotherapy-induced nausea receives a prescription for metoclopramide. Which adverse effect is most important for the nurse to report?

Choice A rationaleDiarrhea is a common side effect of many medications, including metoclopramide. However, it is not considered a serious adverse effect that would require immediate medical attention.Choice B rationaleUnusual irritability can be a side effect of metoclopramide, but it is not the most serious adverse effect of this medication. It is important to monitor for changes in mood or behavior, but these changes do not typically require immediate medical intervention.Choice C rationaleNausea is actually one of the conditions that metoclopramide is used to treat. If a patient experiences nausea while taking this medication, it may indicate that the medication is not effectively managing the patient’s symptoms, but it is not considered a serious adverse effect.Choice D rationaleInvoluntary movements, also known as tardive dyskinesia, are a serious potential side effect of metoclopramide. This condition is characterized by repetitive, involuntary movements, most often affecting the lower face. Tardive dyskinesia can be irreversible, even afterdiscontinuation of the medication, and can be debilitating. Therefore, any signs of involuntary movements should be reported to a healthcare provider immediately.