A client with primary open-angle glaucoma is prescribed latanoprost 0.005% ophthalmic solution. Which instructions should the nurse give to the client to maximize efficacy and minimize adverse effects?

A. Instill one drop in each eye every evening.: Latanoprost is a prostaglandin analog that lowers intraocular pressure by increasing aqueous humor outflow. Administering it once daily in the evening maximizes its efficacy and aligns with the drug’s pharmacokinetics. B. Instill one drop in each eye only when experiencing visual disturbances.: Latanoprost must be used consistently to maintain controlled intraocular pressure. Intermittent or symptom-based dosing does not prevent the progressive optic nerve damage associated with glaucoma. C. Instill one drop in each eye every morning.: Morning administration is less effective than evening dosing, as intraocular pressure reduction is greater when latanoprost is applied at night. Evening use also decreases the likelihood of systemic absorption and side effects. D. Instill one drop in each eye every 12 hours.: Twice-daily dosing is unnecessary and may increase the risk of local adverse effects, such as conjunctival hyperemia, eye irritation, and eyelash changes, without providing additional benefit compared to once-daily evening dosing.