A female client who started chemotherapy three days ago for breast cancer (BRCA) calls the clinic reporting that she is so upset she cannot sleep. The client has several PRN medications available. Which drug should the nurse instruct her to take?

Rationale: A. Ondansetron 8 mg PO three times a day PRN: Ondansetron is an antiemetic used to prevent or treat chemotherapy-related nausea and vomiting. It does not address insomnia or emotional distress, so it would not be appropriate for this client’s complaint. B. Oxycodone, acetylsalicylic acid one tablet PO every 4 hours PRN: This combination is prescribed for moderate pain management. Using it for sleep disturbance is inappropriate and could expose the client to unnecessary opioid-related side effects, including dependency and sedation. C. Lorazepam 2 mg PO bedtime: Lorazepam is a benzodiazepine that reduces anxiety and promotes sleep by producing a calming effect on the central nervous system. Given the client’s emotional upset and difficulty sleeping, this medication is the most suitable PRN. D. Acetaminophen, diphenhydramine 2 capsules bedtime: Diphenhydramine may cause sedation and help induce sleep, but it does not address underlying emotional distress. Additionally, routine use in oncology patients may not be ideal due to anticholinergic side effects.