A married client with chronic hepatitis C is experiencing nausea, anorexia, and fatigue. During the health history, the client states, "I drink one to two glasses of wine with dinner, and I take St. John's wort for depression." The client admits to taking acetaminophen for frequent headaches. What should the nurse do? Select all that apply.

Rationale: A. This is incorrect because clients with chronic hepatitis C may have impaired liver function. High-protein diets are generally safe unless there is advanced liver disease with hepatic encephalopathy. “Eating less frequently” could worsen anorexia and malnutrition; therefore, individualized dietary guidance from a provider or dietitian is preferred. B. This is incorrect and unsafe. Alcohol, even in small amounts, is hepatotoxic and can worsen liver inflammation in hepatitis C. The client should be counseled to avoid alcohol entirely. C. Hepatitis C is transmitted primarily through blood, not casual sexual contact, and antibody testing is not a criterion for resuming sexual activity. Standard precautions and discussion about safe practices may be included, but abstaining until antibody testing is negative is unnecessary. D. The client is using St. John’s wort and acetaminophen, both of which can interact with other medications or worsen liver function. The nurse should advise consulting the healthcare provider before starting any new medications, including over-the-counter or herbal supplements. E. Fatigue is a common symptom of chronic hepatitis C. Encouraging adequate rest helps the client conserve energy and promotes overall well-being while managing the illness.