A nurse in a clinic is teaching a client who is postmenopausal about estrogen therapy. Which of the following information should the nurse include in the teaching?

A. Estrogen therapy decreases the risk for breast cancer: Estrogen therapy does not decrease the risk of breast cancer; in fact, prolonged use can increase the risk, especially when combined with progestin. Clients should be informed about this risk and monitored regularly with mammography. B. Estrogen therapy increases the risk for thrombus formation: Estrogen can increase clotting factor activity, raising the risk of deep vein thrombosis, pulmonary embolism, and stroke. This is a significant adverse effect, particularly in clients with a history of thromboembolic events or other risk factors. C. Estrogen therapy can cause weight loss: Estrogen therapy does not reliably cause weight loss. Weight changes are more commonly neutral or associated with fluid retention, rather than significant loss. D. Estrogen therapy increases the risk for seizures: There is no direct correlation between estrogen therapy and an increased risk of seizures in the general postmenopausal population. Seizure risk is not a standard concern for clients on estrogen therapy.