A nurse in a long-term care facility is providing care for a client who has been receiving donepezil. Which of the following findings indicates that the medication is effective?

Choice A reason: Performing ADLs independently is not a specific indicator of donepezil’s effectiveness, as it treats cognitive symptoms in Alzheimer’s, not physical function. While improved cognition may indirectly aid ADLs, this outcome is too broad and not directly tied to the medication’s primary action, making it incorrect. Choice B reason: Increased food intake is not an expected outcome of donepezil, which targets acetylcholinesterase to improve cognitive function in Alzheimer’s. Appetite changes are unrelated to its mechanism, and this finding does not indicate effectiveness, making it an incorrect measure of the drug’s impact. Choice C reason: Enhanced mood is not a primary effect of donepezil, which focuses on slowing cognitive decline. While mood may improve indirectly, it is not a direct indicator of efficacy. Other medications address mood in Alzheimer’s, making this finding less relevant and incorrect. Choice D reason: Improved short-term memory is a key indicator of donepezil’s effectiveness, as it increases acetylcholine levels to slow cognitive decline in Alzheimer’s. Enhanced memory reflects the drug’s intended action, aligning with clinical expectations, making this the correct measure of therapeutic success.