A nurse in a provider's office is caring for a client who has cancer and has started chemotherapy. A nurse is caring for a client who has cancer and is undergoing chemotherapy. Which of the following findings indicates an improvement in the client's condition? (Select all that apply.)

Rationale: A. White blood cell count: The white blood cell count decreased from 5,500/mm³ (within normal range) to 4,500/mm³ (below the reference range). This reflects chemotherapy-induced myelosuppression rather than improvement and increases infection risk. B. Platelet count: The platelet count declined from 150,000/mm³ (lower limit of normal) to 140,000/mm³ (below normal). This indicates worsening thrombocytopenia, not improvement. C. Bleeding episodes: The client reports fewer bleeding episodes after switching to a soft-bristled toothbrush. Reduced bleeding suggests improved symptom management and safer self-care behaviors, indicating improvement. D. Oral health: Improved oral care practices and reduced gum bleeding reflect better oral health, which is a positive outcome during chemotherapy and indicates improvement. E. Weight change: The client experienced weight loss (70.5 kg to 69 kg). Unintentional weight loss during chemotherapy does not indicate improvement and may suggest nutritional compromise.