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    ATI RN Capstone Pharmacology Proctored Exam 2

    A nurse in the PACU is caring for a client who has received general anesthesia and has manifestations of malignant hyperthermia.Which of the following medications should the nurse expect to administer?

    Explanation & Rationale

    Choice A rationaleDiazepam is a benzodiazepine used to manage anxiety, seizures, and muscle spasms. It is not effective in treating malignant hyperthermia, a condition characterized by rapid onset of hypermetabolism and muscle rigidity triggered by certain anesthetics.Choice B rationaleDantrolene is the drug of choice for malignant hyperthermia. It acts by inhibiting calcium release from the sarcoplasmic reticulum in skeletal muscle, thereby reducing muscle rigidity and metabolic activity. Administer 2.5 mg/kg IV bolus initially.Choice C rationaleCyclobenzaprine is a muscle relaxant used to relieve muscle spasms associated with acute musculoskeletal conditions. It does not have the specific mechanism required to counteract the effects of malignant hyperthermia.Choice D rationaleMetaxalone is a muscle relaxant used to treat discomfort associated with acute skeletal muscle conditions. It is not indicated for the treatment of malignant hyperthermia and does not address the underlying pathophysiology of the condition.

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