A nurse is administering an antidepressant medication to a client. The nurse should understand that which of the following is the major difference between selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs)?

Choice A reason: SSRIs specifically inhibit the reuptake of serotonin, making them more selective and generally safer with fewer side effects. This selectivity reduces the risk of anticholinergic and cardiovascular complications seen with TCAs. Choice B reason: SSRIs are typically less sedating than TCAs. TCAs often cause significant sedation due to their antihistaminic effects, making this statement incorrect. Choice C reason: TCAs are more dangerous in overdose due to their narrow therapeutic index and potential for cardiac toxicity. SSRIs are considered safer in overdose situations. Choice D reason: TCAs are associated with more cardiovascular side effects, including orthostatic hypotension and arrhythmias. SSRIs have a more favorable cardiovascular profile.