A nurse is administering an antidepressant medication to a client. The nurse should understand that which of the following is the major difference between selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCA)?

A. SSRIs are more effective in relieving manifestations. Both SSRIs and TCAs are effective in treating depression, but SSRIs are often preferred due to their more favorable side effect profile. TCAs may actually be more effective for some individuals, especially in severe depression, but their side effects limit their widespread use. SSRIs are not necessarily more effective in all cases. B. SSRIs produce a more sedative effect. SSRIs generally do not have strong sedative properties. In contrast, TCAs often cause significant sedation due to their antihistaminic effects. Some SSRIs, like fluvoxamine and paroxetine, can cause mild drowsiness, but overall, TCAs are more sedating. C. TCAs are lethal in overdose. TCAs pose a significant risk in overdose due to their cardiotoxic effects, including arrhythmias, hypotension, and seizures. Even small amounts beyond the therapeutic range can cause fatal outcomes. This is a major reason why SSRIs are preferred in individuals at risk for suicide. D. TCAs have fewer cardiovascular effects. TCAs have more pronounced cardiovascular side effects, including orthostatic hypotension, tachycardia, and QT prolongation, due to their effects on alpha-adrenergic and sodium channels. In contrast, SSRIs have minimal cardiovascular impact, making them safer for clients with heart conditions.