A nurse is assessing a client who has hypercholesterolemia and is receiving simvastatin. Which of the following findings should the nurse recognize as a potential adverse effect?

A. Orthostatic hypotension: Orthostatic hypotension is not a common adverse effect of simvastatin. Simvastatin primarily affects cholesterol levels and does not typically cause a significant decrease in blood pressure. B. Blurred vision: Blurred vision is not commonly associated with simvastatin. While vision changes are rare side effects of some medications, they are not a typical reaction to statins like simvastatin. C. Urinary retention: Urinary retention is not a common side effect of simvastatin. This issue is more typically associated with certain medications like anticholinergics or alpha-blockers, not statins. D. Muscle weakness: Muscle weakness or pain (myopathy) is a well-known adverse effect of simvastatin and other statins. This can range from mild discomfort to severe muscle damage (rhabdomyolysis). Clients on simvastatin should be monitored for any muscle-related symptoms, and the medication should be discontinued if these symptoms occur.