A nurse is assessing a client who is receiving IV vancomycin. The nurse notes a flushing of the neck and tachycardia. Which of the following actions should the nurse take?

A. Changing the IV site is not necessary unless there are signs of infiltration or phlebitis; it does not address the flushing and tachycardia. B. The symptoms described (flushing of the neck and tachycardia) are consistent with "Red Man Syndrome," a common reaction to rapid infusion of vancomycin — not an anaphylactic reaction. C. Cold compresses will not address the underlying cause, which is the rate of infusion. D. Decreasing the infusion rate is the appropriate action. Red Man Syndrome is caused by histamine release from rapid infusion of vancomycin. Slowing the rate can help prevent or reduce symptoms.