A nurse is assessing a client who is taking clozapine. For which of the following adverse effects should the nurse monitor and report to the provider?

A sore throat in a client taking clozapine must be reported immediately because it may indicate agranulocytosis — a dangerous drop in neutrophils that leaves the client susceptible to serious infections. Agranulocytosis is a black-box warning for clozapine. Weekly WBC and ANC monitoring is mandatory. A sore throat as an early sign of infection in an immunocompromised client warrants urgent assessment. Headache, rhinitis, and tinnitus are not specific adverse effects of concern with clozapine.