A nurse is assessing a client who reports having an unusual rash on the palms of their hands and bottom of their feet. The nurse should further assess for which of the following infections?

Rationale: A. HSV-2 typically presents with painful vesicular lesions in the genital area, not a rash on the palms and soles. While disseminated HSV can occur in severe immunocompromised cases, it is not characterized by a typical palm and sole rash. B. Secondary syphilis is classically associated with a diffuse, nonpruritic rash that often involves the palms of the hands and soles of the feet. This occurs due to systemic dissemination of Treponema pallidum. Other findings may include fever, lymphadenopathy, and mucous membrane lesions. C. Gonorrhea typically presents with urethral or cervical discharge, dysuria, and pelvic or testicular pain. Disseminated gonococcal infection may cause arthritis and pustular skin lesions, but palm and sole involvement is not a hallmark feature. D. Hepatitis B primarily affects the liver and may present with jaundice, fatigue, dark urine, and right upper quadrant discomfort. It is not associated with a characteristic rash on the palms and soles.