A nurse is assessing a female client who is taking hormone therapy for breast cancer. What assessment finding requires the nurse to notify the primary health care provider immediately?

Rationale: A. This is a common and expected side effect of hormone therapy due to changes in estrogen levels. It does not require urgent intervention. B. This may occur as a benign side effect of hormone therapy and is not an immediate concern unless accompanied by new lumps, discharge, or skin changes. C. This finding indicates a possible deep vein thrombosis (DVT), which is a medical emergency. Hormone therapy (especially selective estrogen receptor modulators such as tamoxifen) increases the risk of thromboembolic events due to estrogenic effects on coagulation. The nurse should notify the provider immediately and instruct the client to avoid massaging or walking on the affected leg. D. Mild fluid retention can occur with hormone therapy and should be monitored, but it is not immediately life-threatening unless associated with redness and warmth (which would indicate DVT).