A nurse is assessing a newborn who has Trisomy 21 (Down's Syndrome). Which of the following are common characteristics? (Select All that Apply.)

A. Large ears – Down syndrome is associated with small ears. B. Low birth weight – Many infants with Down syndrome have normal birth weight. C. Transverse palmar crease – A single crease across the palm is a hallmark of Down syndrome. D. Protruding tongue – Common due to low muscle tone and oral cavity differences. E. Hypertonia – Down syndrome is characterized by hypotonia (low muscle tone), not hypertonia.